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alcian and van giesen staining of the growth plate from a 7 week old mouse tibia
SEM of trabecular bone from the a 14 week old mouse femur
Psuedo-coloured x-ray of mouse spine, elbow and knee
Triiodide staining of mouse femur
Calcein double labelled mouse femur
MicroCT of mouse femur


Bone and cartilage disorders affect millions of people worldwide. It is estimated that an osteoporotic fracture occurs every 3 seconds with 1 in 3 women and 1 in 5 men over 50 being affected by the condition. Similarly, up to 1 in 5 women and 1 in 10 men over the age of 60 will be affected by osteoarthritis. There is currently a lack of understanding of the mechanisms that underlie these bone and cartilage diseases, resulting in a lack of suitable, effective treatments. Consequently, there is an urgent need to improve understanding of the causes of bone and joint disease, and identify new disease models to develop better treatments.

What is known, is that these diseases are highly heritable, with strong genetic components. However only a small fraction of the genes involved have been identified to date.

The Origins of Bone and Cartilage Disease (OCBD) project will test over 1600 mutant strains with single gene deletions for abnormalities of bone structure and strength, and abnormalities of joint shape, structure and surface integrity. This work will identify new genes that specify bone and joint structure and function, and will provide new disease models for skeletal disorders.

Results from this research will be open access and made publically available on this site and via the International Mouse Phenyotyping Consortium.

Our mission

The origins of bone and cartilage disease project mission has five main aims.
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Our research

The preliminary screening of 100 lines has been completed.
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Our publications

In addition to this website, results from the research of the origins of bone and cartilage project are submitted to peer-reviewed journals.
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Your donation will help the OBCD Project identify genes involved in bone and joint structure, function, and in the development of disease.
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