Gene of the month


Kdm7a

The lysine (K)-specific demethylase 7A (Kdm7a) gene is a protein encoding gene for the Kdm7a enzyme. Kdm7a has been shown to be involved in brain development and downregulation of tumour angiogenesis by it's interaction with histones.

More information about the Kdm7a gene can be found here.

Our results show that Kdm7a homozygous knockout mice have decreased length of both the femur and vertebrae. They also display decreased bone mineral content in the vertebrae, maximum load in the vertebrae and stiffness in the femur. MicroCT analysis identified increased BV/TV and trabecular number in the femur, with decreased trabecular spacing.



Previous 'Gene of the Month' candidates can be viewed here.