International Mouse Phenotyping Consortium (IMPC) and International Knockout Mouse Consortium (IKMC)
The genetic similarity between mice and humans allows researchers to understand a human gene function based on studies using mice. One powerful technique is to delete, or "knockout", the activity of a single mouse gene to assess its biological significance. Such studies reveal how the same human gene may be involved in disease and provide model systems in which to test novel treatments.
The IMPC is generating knockout mouse strains for each of the >20,000 protein coding genes using embryonic stem cells (ES) generated by the IKMC. Production of mice from these ES cells is tracked within the "international Micro-injection tracking system" (iMits) and strains are available to the whole research community via public repositories.
Systematic broad-based phenotyping is performed by each IMPC centre using the International Mouse Phenotyping Resource of Standardised Screens (IMPReSS). Open access to analyses of genotype-phenotype associations is available via this web portal.
More information about the International Mouse Phenotyping Consortium and International Knockout Mouse Consortium can be found on their website – their website www.mousephenotype.org.