Wellcome Trust Sanger Institute

The Wellcome Trust Sanger Institute is a charitably funded genomic research centre located in Hinxton, nine miles south of Cambridge in the UK.

The Wellcome Trust Sanger Institute started research in mouse genetics after its initial objective, the completion of the Human Genome Project, was achieved in 2003. In 2006 it became a member of the International Knockout Mouse Consortium (IKMC) which aims to produce murine knockout embryonic stem (ES) cells for each protein coding gene in the mouse genome.

In 2010, the Wellcome Trust Sanger Institute became a founding member of the International Mouse Phenotyping consortium (IMPC) which was formed to generate mice from the ES cell resources of the IKMC and investigate their phenotype. The aim is to generate 4,000 knockout mouse lines between 2011 and 2016 and the remaining lines between 2016 and 2021. The consortium comprises phenotyping centres in Europe, North America and Asia. Currently the Sanger Institute is the largest centre, generating and phenotyping 160 knockout mouse lines per year. One third of genes are chosen for their likely involvement in human diseases, one third are chosen from suggestions of participating scientists and one third are randomly selected from the IKMC ES cell pool.

WTSI will play an integral role in the OBCD project, providing the samples that will be phenotyped using the bone and cartilage/joint pipelines. In addition to the OBCD project they are also providing samples for immunological and embryonic phenotyping.