Imperial College London
Imperial College London delivers world-class scholarship, education and research in science, medicine, engineering and business, with particular regard to their application in healthcare, industry and commerce. Imperial champions multidisciplinary working, cross faculty collaboration and international partnership.
The Molecular Endocrinology Laboratory, led by Graham Williams and Duncan Bassett, is undertaking high throughput and detailed phenotype analysis of skeletal samples from the Wellcome Trust Sanger Institute, as part of the International Mouse Phenotyping Consortium. Rapid throughput analysis of bone includes digital X-ray microradiography, high-resolution microCT and biomechanical testing. Joint analyses include X-ray microradiography, microCT and back-scattered electron scanning electron microscopy (BSE SEM), together with 3D statistical shape modelling performed by Anthony Bull's laboratory in the Department of Bioengineering. Detailed phenotyping also includes histology, dynamic and static histomorphmetry, quantative BSE SEM, primary bone cell culture and analysis of gene expression and signalling pathways. Alan Boyde, a world-leading expert in hard tissue imaging, provides vital expertise to support development of new phenotyping methods and train the next generation of scientists.
Garvan Institute of Medical Research
Garvan's mission is to make significant contributions to medical research that will change the directions of science and medicine and have major impacts on human health. Garvan strives to enhance and develop research programs that combine fundamental science with strong clinical interactions.
The Bone Biology Division led by Peter Croucher, and RNA Biology and Plasticity Laboratory led by John Mattick, is undertaking analysis of gene expression in bone and cartilage using state-of-the-art facilities for transcriptomics, including determination of gene networks, splice variants, regulatory elements and non-coding RNAs.
Wellcome Trust Sanger Institute
A leader in the Human Genome Project, we are now focused on understanding the role of genetics in health and disease. Our passion for discovery drives our quest to uncover the basis of genetic and infectious disease. We aim to provide results that can be translated into diagnostics, treatments or therapies that reduce global health burdens.
WTSI is home to the large-scale mouse genetics project, which is producing 160 mutant mouse lines per year. Samples from these animals are being diverted to a number of phenotypic research pipelines, including the OBCD project. David Melvin will be in charge of data capture and handling, including overseeing the distribution of samples.
In addition to housing the team of scientists providing the tissue for the OBCD project, WTSI will also be providing expertise on diverse areas including human genetics and systems biology.